Bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution.

Nishihara, Ryo; Suzuki, Hideyuki; Hoshino, Emi; Suganuma, Sakura; Sato, Moritoshi; Saitoh, Tsuyoshi; Nishiyama, Shigeru; Iwasawa, Naoko; Citterio, Daniel; Suzuki, Koji

Nishihara, Ryo; Suzuki, Hideyuki; Hoshino, Emi; Suganuma, Sakura; Sato, Moritoshi; Saitoh, Tsuyoshi; Nishiyama, Shigeru; Iwasawa, Naoko; Citterio, Daniel; Suzuki, Koji.

Afiliación

Nishihara R; Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan. suzuki@applc.keio.ac.jp.

Chem Commun (Camb) ; 51(2): 391-4, 2015.

Article en En | MEDLINE | ID: mdl-25407088

ABSTRACT

ABSTRACT

Three novel coelenterazine (CTZ) derivatives with extension at the C-6 position of the imidazopyrazinone structure show significant bioluminescence emission with known renilla luciferase variants, indicating a promising method to develop CTZ derivatives with superior optical properties compared to hitherto reported compounds.

Asunto(s)

Imidazoles/química; Sustancias Luminiscentes/química; Pirazinas/química; Animales; Imidazoles/metabolismo; Luciferasas de Renilla/metabolismo; Sustancias Luminiscentes/metabolismo; Mediciones Luminiscentes; Pirazinas/metabolismo; Renilla/enzimología; Especificidad por Sustrato

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazinas / Sustancias Luminiscentes / Imidazoles Límite: Animals Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Japón

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