Vitamin D deficiency is associated with progression of knee osteoarthritis.
J Nutr
; 144(12): 2002-8, 2014 Dec.
Article
en En
| MEDLINE
| ID: mdl-25411034
ABSTRACT
BACKGROUND:
Knee osteoarthritis causes functional limitation and disability in the elderly. Vitamin D has biological functions on multiple knee joint structures and can play important roles in the progression of knee osteoarthritis. The metabolism of vitamin D is regulated by parathyroid hormone (PTH).OBJECTIVE:
The objective was to investigate whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] and PTH, individually and jointly, predict the progression of knee osteoarthritis.METHODS:
Serum 25(OH)D and PTH were measured at the 30- or 36-mo visit in 418 participants enrolled in the Osteoarthritis Initiative (OAI) who had ≥1 knee with both symptomatic and radiographic osteoarthritis. Progression of knee osteoarthritis was defined as any increase in the radiographic joint space narrowing (JSN) score between the 24- and 48-mo OAI visits.RESULTS:
The mean concentrations of serum 25(OH)D and PTH were 26.2 µg/L and 54.5 pg/mL, respectively. Approximately 16% of the population had serum 25(OH)D < 15 µg/L. Between the baseline and follow-up visits, 14% progressed in JSN score. Participants with low vitamin D [25(OH)D < 15 µg/L] had >2-fold elevated risk of knee osteoarthritis progression compared with those with greater vitamin D concentrations (≥15 µg/L; OR 2.3; 95% CI 1.1, 4.5). High serum PTH (≥73 pg/mL) was not associated with a significant increase in JSN score. However, participants with both low vitamin D and high PTH had >3-fold increased risk of progression (OR 3.2; 95%CI 1.2, 8.4).CONCLUSION:
Our results suggest that individuals deficient in vitamin D have an increased risk of knee osteoarthritis progression.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Deficiencia de Vitamina D
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Progresión de la Enfermedad
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Osteoartritis de la Rodilla
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Nutr
Año:
2014
Tipo del documento:
Article
País de afiliación:
Marruecos