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Acoustic force spectroscopy.
Sitters, Gerrit; Kamsma, Douwe; Thalhammer, Gregor; Ritsch-Marte, Monika; Peterman, Erwin J G; Wuite, Gijs J L.
Afiliación
  • Sitters G; 1] Department of Physics and Astronomy, VU University Amsterdam, Amsterdam, the Netherlands. [2] LaserLaB Amsterdam, VU University Amsterdam, Amsterdam, the Netherlands.
  • Kamsma D; 1] Department of Physics and Astronomy, VU University Amsterdam, Amsterdam, the Netherlands. [2] LaserLaB Amsterdam, VU University Amsterdam, Amsterdam, the Netherlands.
  • Thalhammer G; Division for Biomedical Physics, Innsbruck Medical University, Innsbruck, Austria.
  • Ritsch-Marte M; Division for Biomedical Physics, Innsbruck Medical University, Innsbruck, Austria.
  • Peterman EJ; 1] Department of Physics and Astronomy, VU University Amsterdam, Amsterdam, the Netherlands. [2] LaserLaB Amsterdam, VU University Amsterdam, Amsterdam, the Netherlands.
  • Wuite GJ; 1] Department of Physics and Astronomy, VU University Amsterdam, Amsterdam, the Netherlands. [2] LaserLaB Amsterdam, VU University Amsterdam, Amsterdam, the Netherlands.
Nat Methods ; 12(1): 47-50, 2015 Jan.
Article en En | MEDLINE | ID: mdl-25419961
ABSTRACT
Force spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Here we extend the force spectroscopy toolbox with an acoustic manipulation device that can exert forces from subpiconewtons to hundreds of piconewtons on thousands of biomolecules in parallel, with submillisecond response time and inherent stability. This method can be readily integrated in lab-on-a-chip devices, allowing for cost-effective and massively parallel applications.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Análisis Espectral / Acústica Idioma: En Revista: Nat Methods Asunto de la revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Análisis Espectral / Acústica Idioma: En Revista: Nat Methods Asunto de la revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos