Predictive factors of portal vein thrombus following splenectomy in patients with severe cirrhosis.
Hepatogastroenterology
; 61(134): 1552-5, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-25436341
ABSTRACT
BACKGROUND/AIMS:
Splenectomy is performed in patients with severe cirrhosis who have a low platelet count. A portal vein thrombus (PVT) is one of the complications associated with splenectomy. This study aimed to identify predictive factors of postoperative PVT following splenectomy.METHODOLOGY:
Twentyeight patients who underwent splenectomy between April 2003 and March 2013 were retrospectively analyzed. Patients were divided into two groups the PVT(+) group comprising 11 patients who developed postoperative PVT, and the PVT(-) group comprising 17 patients who did not develop postoperative PVT. The patient characteristics of the 2 groups were analyzed.Results:
In univariate analysis, the platelet count, rate of simultaneous treatment of hepatocellular carcinoma, and preoperative spleen volume were significantly different between the groups (p < 0.05). In multivariate analysis, preoperative spleen volume alone was an independent factor associated with the development of PVT (p = 0.007). At a preoperative spleen volume cutoff of 450 mL, the sensitivity and specificity were 90% and 73%, respectively.CONCLUSIONS:
In patients with severe cirrhosis scheduled to undergo splenectomy, if the preoperative spleen volume is >450 mL, as measured by enhanced computed tomography, preventive administration of anticoagulant therapy is recommended to reduce the risk of PVT development.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Bazo
/
Esplenectomía
/
Trombosis de la Vena
/
Cirrosis Hepática
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Hepatogastroenterology
Año:
2014
Tipo del documento:
Article