Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular Dynamics.

Noto, Rosina; Santangelo, Maria Grazia; Levantino, Matteo; Cupane, Antonio; Mangione, Maria Rosalia; Parisi, Daniele; Ricagno, Stefano; Bolognesi, Martino; Manno, Mauro; Martorana, Vincenzo

Noto, Rosina; Santangelo, Maria Grazia; Levantino, Matteo; Cupane, Antonio; Mangione, Maria Rosalia; Parisi, Daniele; Ricagno, Stefano; Bolognesi, Martino; Manno, Mauro; Martorana, Vincenzo.

Afiliación

Noto R; Institute of Biophysics, National Research Council of Italy, Palermo, Italy.
Santangelo MG; Institute of Biophysics, National Research Council of Italy, Palermo, Italy.
Levantino M; Department of Physics and Chemistry, University of Palermo, Palermo, Italy.
Cupane A; Department of Physics and Chemistry, University of Palermo, Palermo, Italy.
Mangione MR; Institute of Biophysics, National Research Council of Italy, Palermo, Italy.
Parisi D; Institute of Biophysics, National Research Council of Italy, Palermo, Italy; Department of Biosciences, Institute of Biophysics CNR, Italy and CIMAINA, University of Milano, Milan, Italy.
Ricagno S; Department of Biosciences, Institute of Biophysics CNR, Italy and CIMAINA, University of Milano, Milan, Italy.
Bolognesi M; Department of Biosciences, Institute of Biophysics CNR, Italy and CIMAINA, University of Milano, Milan, Italy.
Manno M; Institute of Biophysics, National Research Council of Italy, Palermo, Italy. Electronic address: mauro.manno@cnr.it.
Martorana V; Institute of Biophysics, National Research Council of Italy, Palermo, Italy.

Biochim Biophys Acta ; 1854(2): 110-7, 2015 Feb.

Article en En | MEDLINE | ID: mdl-25450507

Asunto(s)

Epilepsias Mioclónicas/metabolismo; Trastornos Heredodegenerativos del Sistema Nervioso/metabolismo; Neuropéptidos/química; Conformación Proteica; Inhibidores de Serina Proteinasa/química; Serpinas/química; Dicroismo Circular; Epilepsias Mioclónicas/genética; Epilepsias Mioclónicas/patología; Trastornos Heredodegenerativos del Sistema Nervioso/genética; Trastornos Heredodegenerativos del Sistema Nervioso/patología; Humanos; Enlace de Hidrógeno; Simulación de Dinámica Molecular; Neuropéptidos/metabolismo; Pliegue de Proteína; Isoformas de Proteínas/química; Isoformas de Proteínas/genética; Estructura Secundaria de Proteína; Inhibidores de Serina Proteinasa/metabolismo; Serpinas/metabolismo; Neuroserpina

Palabras clave

Circular dichroism; Conformational disease; Fluorescence; Molecular Dynamics; Neuroserpin; Serpin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Conformación Proteica / Neuropéptidos / Inhibidores de Serina Proteinasa / Serpinas / Epilepsias Mioclónicas / Trastornos Heredodegenerativos del Sistema Nervioso Límite: Humans Idioma: En Revista: Biochim Biophys Acta Año: 2015 Tipo del documento: Article País de afiliación: Italia

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