The twin-arginine protein translocation pathway.
Annu Rev Biochem
; 84: 843-64, 2015.
Article
en En
| MEDLINE
| ID: mdl-25494301
ABSTRACT
The twin-arginine translocation (Tat) system, found in prokaryotes, chloroplasts, and some mitochondria, allows folded proteins to be moved across membranes. How this transport is achieved without significant ion leakage is an intriguing mechanistic question. Tat transport is mediated by complexes formed from small integral membrane proteins from just two protein families. Atomic-resolution structures have recently been determined for representatives of both these protein families, providing the first molecular-level glimpse of the Tat machinery. I review our current understanding of the mechanism of Tat transport in light of these new structural data.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Transporte de Proteínas
/
Sistema de Translocación de Arginina Gemela
Idioma:
En
Revista:
Annu Rev Biochem
Año:
2015
Tipo del documento:
Article