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Evaluating effect of symptoms heterogeneity on decision-making ability in obsessive-compulsive disorder.
Martoni, Riccardo Maria; Brombin, Chiara; Nonis, Alessandro; Salgari, Giulia Carlotta; Buongiorno, Angela; Cavallini, Maria Cristina; Galimberti, Elisa; Bellodi, Laura.
Afiliación
  • Martoni RM; Department of Clinical Neurosciences, San Raffaele Scientific Institute, Milan, Italy.
  • Brombin C; Decision Theory in Neuroscience, Vita-Salute San Raffaele University, Milan, Italy.
  • Nonis A; Faculty of Psychology, Vita-Salute San Raffaele University, Milan, Italy.
  • Salgari GC; CUSSB, University Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy.
  • Buongiorno A; CUSSB, University Center for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy.
  • Cavallini MC; Department of Clinical Neurosciences, San Raffaele Scientific Institute, Milan, Italy.
  • Galimberti E; Department of Clinical Neurosciences, San Raffaele Scientific Institute, Milan, Italy.
  • Bellodi L; Department of Clinical Neurosciences, San Raffaele Scientific Institute, Milan, Italy.
Psychiatry Clin Neurosci ; 69(7): 402-10, 2015 Jul.
Article en En | MEDLINE | ID: mdl-25522816
ABSTRACT

AIMS:

Despite having a univocal definition, obsessive-compulsive disorder (OCD) shows a remarkably phenotypic heterogeneity. The published reports show impaired decision-making in OCD patients, using tasks such as the Iowa Gambling Task (IGT). We wanted to verify the hypothesis of an IGT worse performance in a large sample of OCD patients and healthy control (HC) subjects and to examine the relation between neuropsychological performance in IGT and the OCD symptoms heterogeneity.

METHODS:

Binary data from the Yale-Brown Obsessive Compulsive Scale collected on a large sample of OCD patients were analyzed using a multidimensional item response theory model to explore the underlying structure of data, thus revealing latent factors. Factor scores were categorized into quartiles. Then, for each factor, we identified patients respectively with the highest versus lowest score. We evaluated whether symptom dimensions affect the probability of a correct answer over time generalized, during IGT performance, fitting a generalized linear mixed model.

RESULTS:

We found a general deficit in ambiguous decision-making in OCD compared to HC. Moreover, our findings suggested that OCD symptoms heterogeneity affects decision-making learning abilities during IGT. In fact, while 'Symmetry' and 'Washing' patients showed a learning curve during the task, other subgroups did not.

CONCLUSIONS:

Our study confirmed previous findings suggesting that OCD is characterized by a deficit in decision-making under uncertainty. Moreover, our study gave evidence about biological specificity for each symptom dimension in OCD. Data were discussed in the context of the somatic marker hypothesis, which was hypothesized to be reduced in OCD patients.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Toma de Decisiones / Evaluación de Síntomas / Trastorno Obsesivo Compulsivo Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2015 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Toma de Decisiones / Evaluación de Síntomas / Trastorno Obsesivo Compulsivo Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2015 Tipo del documento: Article País de afiliación: Italia