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Molecular Mechanisms of IgE Class Switch Recombination.
Tong, Pei; Wesemann, Duane R.
Afiliación
  • Tong P; Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Curr Top Microbiol Immunol ; 388: 21-37, 2015.
Article en En | MEDLINE | ID: mdl-25553793
Immunoglobulin (Ig) E is the most tightly regulated of all Ig heavy chain (IgH) isotypes and plays a key role in atopic disease. The gene encoding for IgH in mature B cells consists of a variable region exon-assembled from component gene segments via V(D)J recombination during early B cell development-upstream of a set of IgH constant region CH exons. Upon activation by antigen in peripheral lymphoid organs, B cells can undergo IgH class switch recombination (CSR), a process in which the initially expressed IgH µ constant region exons (Cµ) are deleted and replaced by one of several sets of downstream CH exons (e.g., Cγ, Cε, and Cα). Activation of the IL-4 receptor on B cells, together with other signals, can lead to the replacement of Cµ with Cε resulting in CSR to IgE through a series of molecular events involving irreversible remodeling of the IgH locus. Here, we discuss the molecular mechanisms of CSR and the unique features surrounding the generation of IgE-producing B cells.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inmunoglobulina E / Cambio de Clase de Inmunoglobulina Límite: Animals / Humans Idioma: En Revista: Curr Top Microbiol Immunol Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inmunoglobulina E / Cambio de Clase de Inmunoglobulina Límite: Animals / Humans Idioma: En Revista: Curr Top Microbiol Immunol Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos