Cytotoxicity of synthesized Iron Oxide nanoparticles: toward novel biomarkers of colon cancer.
Annu Int Conf IEEE Eng Med Biol Soc
; 2014: 6179-82, 2014.
Article
en En
| MEDLINE
| ID: mdl-25571408
ABSTRACT
In this paper we present the preliminary results of a novel biological analysis platform for early colon cancer detection using magnetic separation of magnetized markers. The platform consists of a microfluidic structure integrated with biosensors. Super-Paramagnetic Iron Oxide nanoparticles (SPIO-NPs) were functionalized with purified DNA Aptamer and their synthesis is described. In this paper, we also present the physicochemical results of the synthesized SPIO/Au-NPs characterized by TEM and XRD. Toxicity of our synthesized biomarkers on HCT116 cell line is discussed. Based on our findings, a concentration of 1mg/ml of our biomarkers added to 5 × 105 cells per well has no effect the viability of the human cells even after 24 hours.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Biomarcadores
/
Técnicas Analíticas Microfluídicas
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Óxido Ferrosoférrico
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Nanopartículas de Magnetita
Límite:
Humans
Idioma:
En
Revista:
Annu Int Conf IEEE Eng Med Biol Soc
Año:
2014
Tipo del documento:
Article