Common and disorder-specific neural responses to emotional faces in generalised anxiety, social anxiety and panic disorders.
Br J Psychiatry
; 206(3): 206-15, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25573399
ABSTRACT
BACKGROUND:
Although evidence exists for abnormal brain function across various anxiety disorders, direct comparison of neural function across diagnoses is needed to elicit abnormalities common across disorders and those distinct to a particular diagnosis.AIMS:
To delineate common and distinct abnormalities within generalised anxiety (GAD), panic and social anxiety disorder (SAD) during affective processing.METHOD:
Fifty-nine adults (15 with GAD, 15 with panic disorder, 14 with SAD, and 15 healthy controls) underwent functional magnetic resonance imaging while completing a facial emotion matching task with fearful, angry and happy faces.RESULTS:
Greater differential right amygdala activation to matching fearful v. happy facial expressions related to greater negative affectivity (i.e. trait anxiety) and was heightened across all anxiety disorder groups compared with controls. Collapsing across emotional face types, participants with panic disorder uniquely displayed greater posterior insula activation.CONCLUSIONS:
These preliminary results highlight a common neural basis for clinical anxiety in these diagnoses and also suggest the presence of disorder-specific dysfunction.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastornos de Ansiedad
/
Encéfalo
/
Corteza Cerebral
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Trastorno de Pánico
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Expresión Facial
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Amígdala del Cerebelo
Tipo de estudio:
Observational_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Br J Psychiatry
Año:
2015
Tipo del documento:
Article