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Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability.
Devlin, Anna-Claire; Burr, Karen; Borooah, Shyamanga; Foster, Joshua D; Cleary, Elaine M; Geti, Imbisaat; Vallier, Ludovic; Shaw, Christopher E; Chandran, Siddharthan; Miles, Gareth B.
Afiliación
  • Devlin AC; 1] School of Psychology and Neuroscience, University of St. Andrews, Westburn Lane, St. Andrews KY16 9JP, UK [2] Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh EH16 4SB, UK.
  • Burr K; 1] Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh EH16 4SB, UK [2] Centre for Neuroregeneration and Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK.
  • Borooah S; 1] Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh EH16 4SB, UK [2] Centre for Neuroregeneration and Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK.
  • Foster JD; School of Psychology and Neuroscience, University of St. Andrews, Westburn Lane, St. Andrews KY16 9JP, UK.
  • Cleary EM; 1] Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh EH16 4SB, UK [2] Centre for Neuroregeneration and Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK.
  • Geti I; Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine, Department of Surgery, University of Cambridge, Cambridge CB2 0XY, UK.
  • Vallier L; Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine, Department of Surgery, University of Cambridge, Cambridge CB2 0XY, UK.
  • Shaw CE; MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK.
  • Chandran S; 1] Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh EH16 4SB, UK [2] Centre for Neuroregeneration and Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK.
  • Miles GB; 1] School of Psychology and Neuroscience, University of St. Andrews, Westburn Lane, St. Andrews KY16 9JP, UK [2] Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh EH16 4SB, UK.
Nat Commun ; 6: 5999, 2015 Jan 12.
Article en En | MEDLINE | ID: mdl-25580746
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas / Sistemas de Lectura Abierta / Proteínas de Unión al ADN / Células Madre Pluripotentes Inducidas / Mutación Límite: Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas / Sistemas de Lectura Abierta / Proteínas de Unión al ADN / Células Madre Pluripotentes Inducidas / Mutación Límite: Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido