Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3.

Gao, Rui; Liu, Yongping; Silva-Fernandes, Anabela; Fang, Xiang; Paulucci-Holthauzen, Adriana; Chatterjee, Arpita; Zhang, Hang L; Matsuura, Tohru; Choudhary, Sanjeev; Ashizawa, Tetsuo; Koeppen, Arnulf H; Maciel, Patricia; Hazra, Tapas K; Sarkar, Partha S

Gao, Rui; Liu, Yongping; Silva-Fernandes, Anabela; Fang, Xiang; Paulucci-Holthauzen, Adriana; Chatterjee, Arpita; Zhang, Hang L; Matsuura, Tohru; Choudhary, Sanjeev; Ashizawa, Tetsuo; Koeppen, Arnulf H; Maciel, Patricia; Hazra, Tapas K; Sarkar, Partha S.

Afiliación

Gao R; Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Liu Y; Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Silva-Fernandes A; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal; ICVS/3B's PT Government Associate Laboratory, Braga/Guimaraes, Portugal.
Fang X; Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Paulucci-Holthauzen A; Department of Biomedical Engineering, University of Texas Medical Branch, Galveston, Texas, United States of America.
Chatterjee A; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America.
Zhang HL; Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America.
Matsuura T; Department of Neurology, Jichi Medical School, Shimotsuke, Japan.
Choudhary S; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America.
Ashizawa T; Department of Neurology and McNight Brain Research Institute, University of Florida, Gainesville, Florida, United States of America.
Koeppen AH; Department of Neurology, Albany Stratton VA Medical Center, Albany, New York, United States of America.
Maciel P; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal; ICVS/3B's PT Government Associate Laboratory, Braga/Guimaraes, Portugal.
Hazra TK; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America.
Sarkar PS; Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America; Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, United States of America.

PLoS Genet ; 11(1): e1004834, 2015 Jan.

Article en En | MEDLINE | ID: mdl-25590633

Asunto(s)

Daño del ADN/genética; Enzimas Reparadoras del ADN/genética; Enfermedad de Machado-Joseph/genética; Proteínas del Tejido Nervioso/genética; Proteínas Nucleares/genética; Fosfotransferasas (Aceptor de Grupo Alcohol)/genética; Proteínas Represoras/genética; Apoptosis; Proteínas de la Ataxia Telangiectasia Mutada/genética; Ataxina-3; Reparación del ADN/genética; Enzimas Reparadoras del ADN/biosíntesis; Humanos; Enfermedad de Machado-Joseph/patología; Proteínas del Tejido Nervioso/metabolismo; Proteínas Nucleares/metabolismo; Fosfotransferasas (Aceptor de Grupo Alcohol)/biosíntesis; Agregado de Proteínas/genética; Proteína Quinasa C-delta/genética; Proteínas Represoras/metabolismo; Transducción de Señal/genética; Expansión de Repetición de Trinucleótido/genética

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Represoras / Daño del ADN / Proteínas Nucleares / Fosfotransferasas (Aceptor de Grupo Alcohol) / Enfermedad de Machado-Joseph / Enzimas Reparadoras del ADN / Proteínas del Tejido Nervioso Límite: Humans Idioma: En Revista: PLoS Genet Asunto de la revista: GENETICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google