Hydrogen bonding in aprotic solvents, a new strategy for gelation of bioinspired catecholic copolymers with N-isopropylamide.
Macromol Rapid Commun
; 36(5): 447-52, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25594749
ABSTRACT
Copolymers of N-isopropylacrylamide (NIPAM) and dopamine methacrylate can establish a reversible, self-healing 3D network in aprotic solvents based on hydrogen bonding. The reactivity and hydrogen bonding formation of catechol groups in copolymer chains are studied by UV-vis and (1) H NMR spectroscopy, while reversibility from sol to gel and inverse as well as self-healing properties are tested rheologically. The produced reversible organogel can self-encapsulate physically interacting or chemically bonded solutes such as drugs due to thermosensitivity of the used copolymer. This system offers dual-targeted and controlled drug delivery and release-by slowing down release kinetics by supramolecular bonding of the drug and by reducing diffusion rates due to modulus increase.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polímeros
/
Solventes
/
Acrilamidas
/
Liberación de Fármacos
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Geles
Idioma:
En
Revista:
Macromol Rapid Commun
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos