Hypoxia induces a lipogenic cancer cell phenotype via HIF1&#945;-dependent and -independent pathways.

Valli, Alessandro; Rodriguez, Miguel; Moutsianas, Loukas; Fischer, Roman; Fedele, Vita; Huang, Hong-Lei; Van Stiphout, Ruud; Jones, Dylan; Mccarthy, Michael; Vinaxia, Maria; Igarashi, Kaori; Sato, Maya; Soga, Tomoyoshi; Buffa, Francesca; Mccullagh, James; Yanes, Oscar; Harris, Adrian; Kessler, Benedikt

Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways.

Valli, Alessandro; Rodriguez, Miguel; Moutsianas, Loukas; Fischer, Roman; Fedele, Vita; Huang, Hong-Lei; Van Stiphout, Ruud; Jones, Dylan; Mccarthy, Michael; Vinaxia, Maria; Igarashi, Kaori; Sato, Maya; Soga, Tomoyoshi; Buffa, Francesca; Mccullagh, James; Yanes, Oscar; Harris, Adrian; Kessler, Benedikt.

Afiliación

Valli A; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Rodriguez M; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Moutsianas L; Mass Spectrometry Research Facility CRL, Department of Chemistry, University of Oxford, Oxford, UK.
Fischer R; Centre for Omic Sciences, Rovira i Virgili University, Reus, Spain.
Fedele V; Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Madrid, Spain.
Huang HL; The Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, Oxford, UK.
Van Stiphout R; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Jones D; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Mccarthy M; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Vinaxia M; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Igarashi K; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Sato M; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Soga T; Centre for Omic Sciences, Rovira i Virgili University, Reus, Spain.
Buffa F; Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Madrid, Spain.
Mccullagh J; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan.
Yanes O; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan.
Harris A; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan.
Kessler B; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

Oncotarget ; 6(4): 1920-41, 2015 Feb 10.

Article en En | MEDLINE | ID: mdl-25605240

Asunto(s)

Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Metabolismo de los Lípidos; Lípidos/biosíntesis; Transducción de Señal; Acetil-CoA C-Aciltransferasa/genética; Acetil-CoA C-Aciltransferasa/metabolismo; Acetil-CoA Carboxilasa/genética; Acetil-CoA Carboxilasa/metabolismo; Anciano; Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/genética; Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/metabolismo; Western Blotting; Hipoxia de la Célula; Línea Celular Tumoral; Neoplasias Colorrectales/genética; Neoplasias Colorrectales/metabolismo; Neoplasias Colorrectales/patología; Ácidos Grasos/biosíntesis; Femenino; Genómica/métodos; Células HCT116; Humanos; Subunidad alfa del Factor 1 Inducible por Hipoxia/genética; Masculino; Metabolómica/métodos; Persona de Mediana Edad; Factor de Activación Plaquetaria/genética; Factor de Activación Plaquetaria/metabolismo; Proteómica/métodos; Interferencia de ARN

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Subunidad alfa del Factor 1 Inducible por Hipoxia / Metabolismo de los Lípidos / Lípidos Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Oncotarget Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido

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