PART is part of Alzheimer disease.
Acta Neuropathol
; 129(5): 749-56, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-25628035
ABSTRACT
It has been proposed that tau aggregation confined to entorhinal cortex and hippocampus, with no or only minimal Aß deposition, should be considered as a 'primary age-related tauopathy' (PART) that is not integral to the continuum of sporadic Alzheimer disease (AD). Here, we examine the evidence that PART has a pathogenic mechanism and a prognosis which differ from those of AD. We contend that no specific property of the entorhinal-hippocampal tau pathology makes it possible to predict either a limited progression or the development of AD, and that biochemical differences await an evidence base. On the other hand, entorhinal-hippocampal tau pathology is an invariant feature of AD and is always associated with its development. Rather than creating a separate disease entity, we recommend the continued use of an analytical approach based on NFT stages and Aß phases with no inference about hypothetical disease processes.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Péptidos beta-Amiloides
/
Proteínas tau
/
Tauopatías
/
Enfermedad de Alzheimer
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Acta Neuropathol
Año:
2015
Tipo del documento:
Article