AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress.
Blood
; 125(13): 2120-30, 2015 Mar 26.
Article
en En
| MEDLINE
| ID: mdl-25631767
ABSTRACT
Mitochondrial respiration is a crucial component of cellular metabolism that can become dysregulated in cancer. Compared with normal hematopoietic cells, acute myeloid leukemia (AML) cells and patient samples have higher mitochondrial mass, without a concomitant increase in respiratory chain complex activity. Hence these cells have a lower spare reserve capacity in the respiratory chain and are more susceptible to oxidative stress. We therefore tested the effects of increasing the electron flux through the respiratory chain as a strategy to induce oxidative stress and cell death preferentially in AML cells. Treatment with the fatty acid palmitate induced oxidative stress and cell death in AML cells, and it suppressed tumor burden in leukemic cell lines and primary patient sample xenografts in the absence of overt toxicity to normal cells and organs. These data highlight a unique metabolic vulnerability in AML, and identify a new therapeutic strategy that targets abnormal oxidative metabolism in this malignancy.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Consumo de Oxígeno
/
Leucemia Mieloide Aguda
/
Estrés Oxidativo
Límite:
Humans
Idioma:
En
Revista:
Blood
Año:
2015
Tipo del documento:
Article