Plasminogen activator inhibitor-1 suppresses profibrotic responses in fibroblasts from fibrotic lungs.

Marudamuthu, Amarnath S; Shetty, Shwetha K; Bhandary, Yashodhar P; Karandashova, Sophia; Thompson, Michael; Sathish, Venkatachalem; Florova, Galina; Hogan, Taryn B; Pabelick, Christina M; Prakash, Y S; Tsukasaki, Yoshikazu; Fu, Jian; Ikebe, Mitsuo; Idell, Steven; Shetty, Sreerama

Marudamuthu, Amarnath S; Shetty, Shwetha K; Bhandary, Yashodhar P; Karandashova, Sophia; Thompson, Michael; Sathish, Venkatachalem; Florova, Galina; Hogan, Taryn B; Pabelick, Christina M; Prakash, Y S; Tsukasaki, Yoshikazu; Fu, Jian; Ikebe, Mitsuo; Idell, Steven; Shetty, Sreerama.

Afiliación

Marudamuthu AS; From the Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, Texas 75708.
Shetty SK; From the Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, Texas 75708.
Bhandary YP; From the Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, Texas 75708.
Karandashova S; From the Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, Texas 75708.
Thompson M; the Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, and.
Sathish V; the Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, and.
Florova G; From the Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, Texas 75708.
Hogan TB; From the Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, Texas 75708.
Pabelick CM; the Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, and.
Prakash YS; the Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, and.
Tsukasaki Y; From the Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, Texas 75708.
Fu J; the Center for Research on Environmental Disease and Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536.
Ikebe M; From the Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, Texas 75708.
Idell S; From the Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, Texas 75708.
Shetty S; From the Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, Texas 75708, sreerama.shetty@uthct.edu.

J Biol Chem ; 290(15): 9428-41, 2015 Apr 10.

Article en En | MEDLINE | ID: mdl-25648892

Asunto(s)

Células Epiteliales/metabolismo; Fibroblastos/metabolismo; Fibrosis Pulmonar Idiopática/metabolismo; Inhibidor 1 de Activador Plasminogénico/metabolismo; Alveolos Pulmonares/metabolismo; Actinas/genética; Actinas/metabolismo; Animales; Apoptosis/genética; Bleomicina; Western Blotting; Proliferación Celular/genética; Células Cultivadas; Colágeno Tipo I/genética; Colágeno Tipo I/metabolismo; Células Epiteliales/patología; Fibroblastos/patología; Expresión Génica; Fibrosis Pulmonar Idiopática/genética; Fibrosis Pulmonar Idiopática/patología; Ratones Endogámicos C57BL; Ratones Noqueados; Microscopía Confocal; Músculo Liso/metabolismo; Inhibidor 1 de Activador Plasminogénico/genética; Alveolos Pulmonares/patología; Fibrosis Pulmonar/inducido químicamente; Fibrosis Pulmonar/genética; Fibrosis Pulmonar/metabolismo; Receptores del Activador de Plasminógeno Tipo Uroquinasa/genética; Receptores del Activador de Plasminógeno Tipo Uroquinasa/metabolismo; Reacción en Cadena de la Polimerasa de Transcriptasa Inversa; Activador de Plasminógeno de Tipo Uroquinasa/genética; Activador de Plasminógeno de Tipo Uroquinasa/metabolismo

Palabras clave

Animal Model; Fibroblast; Fibrosis; Lung; PAI-1; Pulmonary Fibrosis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Alveolos Pulmonares / Inhibidor 1 de Activador Plasminogénico / Células Epiteliales / Fibrosis Pulmonar Idiopática / Fibroblastos Límite: Animals Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article

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