Bioactive prenylated xanthones from the young fruits and flowers of Garcinia cowa.
J Nat Prod
; 78(2): 265-71, 2015 Feb 27.
Article
en En
| MEDLINE
| ID: mdl-25651042
ABSTRACT
Five new xanthones, garciniacowones A-E (1-5), together with 14 known xanthones, 6-19, were isolated from the young fruits and fresh flowers of Garcinia cowa. The structures of 1-5 were elucidated by analysis of their 1D and 2D NMR spectra and mass spectrometric data. The compounds 1-19 were tested in vitro for their antimicrobial activity and for their ability to inhibit α-glucosidase. Compounds 16 and 17 showed the most potent α-glucosidase inhibitory activity, with IC50 values of 7.8 ± 0.5 and 8.7 ± 0.3 µM, respectively. Compounds 8, 9, and 19 showed antibacterial activity against Bacillus subtilis TISTR 088 with identical MIC values of 2 µg/mL, while 8, 10, and 19 exhibited antibacterial activity against Bacillus cereus TISTR 688 with identical MIC values of 4 µg/mL.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Garcinia
/
Xantonas
/
Alfa-Glucosidasas
/
Inhibidores de Glicósido Hidrolasas
/
Antibacterianos
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Nat Prod
Año:
2015
Tipo del documento:
Article
País de afiliación:
Tailandia