Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection.
J Virol
; 89(8): 4696-9, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-25653445
ABSTRACT
Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor. Mouse DPP4 (mDPP4) does not support MERS-CoV entry; however, changes at positions 288 and 330 can confer permissivity. Position 330 changes the charge and glycosylation state of mDPP4. We show that glycosylation is a major factor impacting DPP4 receptor function. These results provide insight into DPP4 species-specific differences impacting MERS-CoV host range and may inform MERS-CoV mouse model development.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Modelos Moleculares
/
Infecciones por Coronavirus
/
Dipeptidil Peptidasa 4
/
Internalización del Virus
/
Coronavirus del Síndrome Respiratorio de Oriente Medio
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Virol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos