Nano/micro fluorhydroxyapatite crystal pastes in the treatment of dentin hypersensitivity: an in vitro study.
Clin Oral Investig
; 19(8): 1921-30, 2015 Nov.
Article
en En
| MEDLINE
| ID: mdl-25680707
ABSTRACT
OBJECTIVES:
Dentin hypersensitivity (DH) is a prevalent problem. This study aimed to formulate a paste using fluorhydroxyapatite (FA) crystals dispersed in different carriers to treat DH. The ability to occlude patent dentinal tubules and to release ions was investigated. MATERIALS ANDMETHODS:
Twenty percent FA/sodium alginate, 40% FA/poly(hydroxyethyl methacylate(HEMA)), and 40% FA/poly(DMA-co-MEA) were applied to etched dentin samples and examined with scanning electron microscopy (SEM) to determine the degree of tubule occlusion. Fluoride electrode was used to measure F release and spectroscopy to evaluate Ca and PO4 release. The cytotoxicity of the synthesized poly(DMA-co-MEA) gel was tested. Kruskall-Wallis test was used to test the differences in ion release between the groups.RESULTS:
FA/poly(DMA-co-MEA) paste obstructed up to 80% of the dentinal tubules, while the coverage was up to 70% for FA/poly(HEMA) and less than 50% for FA/sodium alginate. Fluoride and Ca release was the highest for FA/P(HEMA), 7.2 ± 0.7 and 139.8 ± 32.5 ppm, respectively. The highest concentration of PO4 was 46.2 ± 16.4 ppm for FA/Sodium alginate. No statistical significance was found.CONCLUSIONS:
FA/Poly(DMA-co-MEA) and FA/poly(HEMA) pastes may offer immediate short-term relief of DH because of their ability to occlude the tubules and adhere to wet dentin surfaces. The release of the F, Ca, and PO4 ions may offer long-term relief by forming a mineral barrier both within the dentinal tubules and on the dentin surface. CLINICALSIGNIFICANCE:
The tested materials may offer a long-term treatment for DH.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Dentina
/
Sensibilidad de la Dentina
/
Nanopartículas
/
Hidroxiapatitas
Límite:
Humans
Idioma:
En
Revista:
Clin Oral Investig
Asunto de la revista:
ODONTOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Jordania