Muscle ultrasound quantifies disease progression over time in infants and young boys with duchenne muscular dystrophy.
Muscle Nerve
; 52(3): 334-8, 2015 Sep.
Article
en En
| MEDLINE
| ID: mdl-25704979
ABSTRACT
INTRODUCTION:
Quantitative muscle ultrasound (QUS) in boys with Duchenne muscular dystrophy (DMD) shows increased echointensity as muscle is replaced with fat and fibrosis. Studies of quantitative ultrasound in infants/young boys with DMD over time have not been reported.METHODS:
We used calibrated muscle backscatter (cMB), a reproducible measure of ultrasound echointensity, to quantify muscle pathology in 5 young boys with DMD (ages 0.5-2.8 years) over 17-29 months. We compared the results with repeated assessments of function (n = 4) and with muscle ultrasound images from a cross-section of 6 male controls (0.6-3.1 years).RESULTS:
cMB in boys with DMD increased (worsened) over time (P < 0.001), whereas function improved. After age 2 years, cMB in most (4 of 5) boys with DMD was higher than in any control.CONCLUSIONS:
QUS measures disease progression in young boys with DMD despite functional improvements. QUS could be employed as an outcome measure for serial assessment of young boys with DMD.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Distrofia Muscular de Duchenne
/
Músculo Cuádriceps
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Límite:
Child, preschool
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Muscle Nerve
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos