Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies.
Immunol Cell Biol
; 93(4): 372-83, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-25708536
ABSTRACT
The control of cell migration by chemokines involves interactions with two types of receptors seven transmembrane chemokine-type G protein-coupled receptors and cell surface or extracellular matrix-associated glycosaminoglycans. Coordinated interaction of chemokines with both types of receptors is required for directional migration of cells in numerous physiological and pathological processes. Accumulated structural information, culminating most recently in the structure of a chemokine receptor in complex with a chemokine, has led to a view where chemokine oligomers bind to glycosaminoglycans through epitopes formed when chemokine subunits come together, while chemokine monomers bind to receptors in a pseudo two-step mechanism of receptor activation. Exploitation of this structural knowledge has and will continue to provide important information for therapeutic strategies, as described in this review.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Quimiocinas
/
Receptores de Quimiocina
/
Receptores Acoplados a Proteínas G
/
Complejos Multiproteicos
/
Glicosaminoglicanos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Immunol Cell Biol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos