Pharmacokinetics and tissue disposition of meloxicam in beef calves after repeated oral administration.
J Vet Pharmacol Ther
; 38(6): 556-62, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-25708937
ABSTRACT
The objective of this study was to investigate the pharmacokinetics and tissue disposition of meloxicam after repeated oral administration in calves. Thirteen male British × Continental beef calves aged 4 to 6 months and weighing 297-392 kg received 0.5 mg/kg meloxicam per os once daily for 4 days. Plasma meloxicam concentrations were determined in 8 calves over 6 days after first treatment. Calves were randomly assigned to be euthanized at 5, 10, 15 (n = 3/timepoint), and 19 days (n = 4) after final administration. Meloxicam concentrations were determined in plasma (LOQ= 0.025 µg/mL) and muscle, liver, kidney, and fat samples (LOQ = 2 ng/g) after extraction using validated LC-MS-MS methods. The mean (± SD) Cmax , Cmin , and Caverage plasma meloxicam concentrations were 4.52 ± 0.87 µg/mL, 2.95 ± 0.77 µg/mL, and 3.84 ± 0.81 µg/mL, respectively. Mean (± SD) tissue meloxicam concentrations were highest in liver (226.67 ± 118.16 ng/g) and kidney samples (52.73 ± 39.01 ng/g) at 5 days after final treatment. Meloxicam concentrations were below the LOQ in all tissues at 15 days after treatment. These findings suggest that tissue from meloxicam-treated calves will have low residue concentrations by 21 days after repeated oral administration.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tiazinas
/
Tiazoles
/
Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
J Vet Pharmacol Ther
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos