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A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent.
Halvorson, Kyle G; Barton, Kelly L; Schroeder, Kristin; Misuraca, Katherine L; Hoeman, Christine; Chung, Alex; Crabtree, Donna M; Cordero, Francisco J; Singh, Raj; Spasojevic, Ivan; Berlow, Noah; Pal, Ranadip; Becher, Oren J.
Afiliación
  • Halvorson KG; Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America; Department of Pathology, Duke University Medical Center, Durham, NC, United States of America; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, United States of America
  • Barton KL; Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America; Department of Pathology, Duke University Medical Center, Durham, NC, United States of America.
  • Schroeder K; Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, United States of America.
  • Misuraca KL; Graduate Program in Molecular Cancer Biology, Duke University, Durham, NC, United States of America.
  • Hoeman C; Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America; Department of Pathology, Duke University Medical Center, Durham, NC, United States of America.
  • Chung A; Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America; Department of Pathology, Duke University Medical Center, Durham, NC, United States of America.
  • Crabtree DM; Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America; Department of Pathology, Duke University Medical Center, Durham, NC, United States of America.
  • Cordero FJ; Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America; Department of Pathology, Duke University Medical Center, Durham, NC, United States of America.
  • Singh R; Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America; Department of Pathology, Duke University Medical Center, Durham, NC, United States of America.
  • Spasojevic I; Department of Medicine-Oncology, Duke University, Durham, NC, United States of America; Duke Cancer Institute, Pharmaceutical Services-PK/PD Core Laboratory, Durham, NC, United States of America.
  • Berlow N; Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX, United States of America.
  • Pal R; Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX, United States of America.
  • Becher OJ; Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America; Department of Pathology, Duke University Medical Center, Durham, NC, United States of America; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, United States of America
PLoS One ; 10(3): e0118926, 2015.
Article en En | MEDLINE | ID: mdl-25748921
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Triazinas / Neoplasias del Tronco Encefálico / Ensayos Analíticos de Alto Rendimiento / Glioma / Antineoplásicos Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Triazinas / Neoplasias del Tronco Encefálico / Ensayos Analíticos de Alto Rendimiento / Glioma / Antineoplásicos Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos