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K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Dong, Yin Yao; Pike, Ashley C W; Mackenzie, Alexandra; McClenaghan, Conor; Aryal, Prafulla; Dong, Liang; Quigley, Andrew; Grieben, Mariana; Goubin, Solenne; Mukhopadhyay, Shubhashish; Ruda, Gian Filippo; Clausen, Michael V; Cao, Lishuang; Brennan, Paul E; Burgess-Brown, Nicola A; Sansom, Mark S P; Tucker, Stephen J; Carpenter, Elisabeth P.
Afiliación
  • Dong YY; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
  • Pike AC; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
  • Mackenzie A; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK. Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK.
  • McClenaghan C; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK. OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK.
  • Aryal P; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK. OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK. Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
  • Dong L; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
  • Quigley A; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
  • Grieben M; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
  • Goubin S; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
  • Mukhopadhyay S; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
  • Ruda GF; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK. Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
  • Clausen MV; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK.
  • Cao L; Pfizer Neusentis, Granta Park, Cambridge CB21 6GS, UK.
  • Brennan PE; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK. Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
  • Burgess-Brown NA; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK.
  • Sansom MS; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK. Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
  • Tucker SJ; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, UK. OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK. liz.carpenter@sgc.ox.ac.uk stephen.tucker@physics.ox.ac.uk.
  • Carpenter EP; Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK. OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PN, UK. liz.carpenter@sgc.ox.ac.uk stephen.tucker@physics.ox.ac.uk.
Science ; 347(6227): 1256-9, 2015 Mar 13.
Article en En | MEDLINE | ID: mdl-25766236

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Activación del Canal Iónico / Canales de Potasio de Dominio Poro en Tándem Límite: Humans Idioma: En Revista: Science Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Activación del Canal Iónico / Canales de Potasio de Dominio Poro en Tándem Límite: Humans Idioma: En Revista: Science Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido