Copper-catalyzed selective arylations of benzoxazoles with aryl iodides.
J Org Chem
; 80(7): 3670-6, 2015 Apr 03.
Article
en En
| MEDLINE
| ID: mdl-25768792
ABSTRACT
A copper-catalyzed direct ring-opening double N-arylation of benzoxazoles with aryl iodides has been developed. The present system exhibits high selectivity despite competition from C-arylation. The selectivity between ring-opening N-arylation and C-arylation was controlled by the choice of reaction vessel. The nitrile bound bis(triphenylphosphine)copper cyanide was identified as the active catalytic species for both reactions, and when combined with a nitrile-containing solvent, enhanced the reaction efficiency.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Benzoxazoles
/
Cobre
/
Complejos de Coordinación
/
Yoduros
/
Nitrilos
Idioma:
En
Revista:
J Org Chem
Año:
2015
Tipo del documento:
Article