Impact of 10- and 13-valent pneumococcal conjugate vaccines on incidence of invasive pneumococcal disease in children aged under 16 years in Germany, 2009 to 2012.
Euro Surveill
; 20(10): 21057, 2015 Mar 12.
Article
en En
| MEDLINE
| ID: mdl-25788255
ABSTRACT
We assessed the impact of 10-valent and 13-valent pneumococcal vaccines (PCV10 and PCV13), which were introduced in Germany in 2009, on the incidence of meningitis and non-meningitis invasive pneumococcal disease (IPD) in children aged under 16 years in a population previously vaccinated with a seven-valent vaccine (PCV7). Surveillance of IPD (isolation of Streptococcus pneumonia from a normally sterile body site) is based on data from two independent reporting sources hospitals and laboratories. IPD incidence was estimated by capture-recapture analysis. Incidence rate ratios (IRRs) were calculated for 2009 and 2012, thus comparing pre- and post-PCV10 and PCV13 data. IPD incidence caused by serotypes included in PCV13 decreased in all age and diagnosis groups. A rise in non-vaccine serotype incidence was seen only in children aged under two years. The overall impact varied by age group and infection site for meningitis IPD in children aged under 2, 2-4 and 5-15 years, incidence changed by 3% (95% CI -31 to 52), -60% (95% CI -81 to -17) and -9% (95% CI -46 to 53), respectively. A more pronounced incidence reduction was observed for non-meningitis IPD -30% (95% CI -46 to -7), -39% (95% CI -54 to -20) and -83% (95% CI -89 to -73) in children aged under 2, 2-4 and 5-15 years, respectively. A higher tropism of the additional serotypes for non-meningitis IPD may be a potential explanation. The heterogeneous findings emphasise the need for rigorous surveillance
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infecciones Neumocócicas
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Vacunas Neumococicas
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Meningitis Neumocócica
Tipo de estudio:
Incidence_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Límite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
País/Región como asunto:
Europa
Idioma:
En
Revista:
Euro Surveill
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2015
Tipo del documento:
Article
País de afiliación:
Alemania