Inter-&#945;-trypsin inhibitor heavy chain 5 (ITIH5) is overexpressed in inflammatory skin diseases and affects epidermal morphology in constitutive knockout mice and murine 3D skin models.

Huth, Sebastian; Heise, Ruth; Vetter-Kauczok, Claudia S; Skazik, Claudia; Marquardt, Yvonne; Czaja, Katharina; Knüchel, Ruth; Merk, Hans F; Dahl, Edgar; Baron, Jens M

Inter-α-trypsin inhibitor heavy chain 5 (ITIH5) is overexpressed in inflammatory skin diseases and affects epidermal morphology in constitutive knockout mice and murine 3D skin models.

Huth, Sebastian; Heise, Ruth; Vetter-Kauczok, Claudia S; Skazik, Claudia; Marquardt, Yvonne; Czaja, Katharina; Knüchel, Ruth; Merk, Hans F; Dahl, Edgar; Baron, Jens M.

Afiliación

Huth S; Department of Dermatology and Allergology, University Hospital of the RWTH, Aachen, Germany.
Heise R; Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH, Aachen, Germany.
Vetter-Kauczok CS; Department of Dermatology and Allergology, University Hospital of the RWTH, Aachen, Germany.
Skazik C; Department of Dermatology, Julius-Maximilians-University, Würzburg, Germany.
Marquardt Y; Department of Dermatology and Allergology, University Hospital of the RWTH, Aachen, Germany.
Czaja K; Department of Dermatology and Allergology, University Hospital of the RWTH, Aachen, Germany.
Knüchel R; Department of Dermatology and Allergology, University Hospital of the RWTH, Aachen, Germany.
Merk HF; Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH, Aachen, Germany.
Dahl E; Department of Dermatology and Allergology, University Hospital of the RWTH, Aachen, Germany.
Baron JM; Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH, Aachen, Germany.

Exp Dermatol ; 24(9): 663-8, 2015 Sep.

Article en En | MEDLINE | ID: mdl-25809190

Asunto(s)

Epidermis/metabolismo; Expresión Génica; Proteínas Inhibidoras de Proteinasas Secretoras/genética; Proteínas Inhibidoras de Proteinasas Secretoras/metabolismo; Enfermedades de la Piel/genética; Enfermedades de la Piel/metabolismo; alfa-Globulinas/genética; Animales; Proteínas Sanguíneas/genética; Células Cultivadas; Epidermis/química; Epidermis/patología; Femenino; Fibroblastos; Perfilación de la Expresión Génica; Glicoproteínas/genética; Humanos; Ácido Hialurónico/metabolismo; Inflamación/genética; Queratinocitos; Ratones; Ratones Noqueados; Modelos Anatómicos; Análisis de Secuencia por Matrices de Oligonucleótidos; Proteínas Inhibidoras de Proteinasas Secretoras/análisis; ARN Mensajero/metabolismo; Regulación hacia Arriba

Palabras clave

ITIH5; ITIH5 knockout mouse; hyaluronan; inflammatory skin diseases; murine 3D skin model

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades de la Piel / Expresión Génica / Epidermis / Proteínas Inhibidoras de Proteinasas Secretoras Límite: Animals / Female / Humans Idioma: En Revista: Exp Dermatol Asunto de la revista: DERMATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Alemania

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