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ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation.
Hammarén, Henrik M; Ungureanu, Daniela; Grisouard, Jean; Skoda, Radek C; Hubbard, Stevan R; Silvennoinen, Olli.
Afiliación
  • Hammarén HM; School of Medicine, University of Tampere, FI-33014 Tampere, Finland;
  • Ungureanu D; School of Medicine, University of Tampere, FI-33014 Tampere, Finland;
  • Grisouard J; Department of Biomedicine, Experimental Hematology, University Hospital Basel, CH-4031 Basel, Switzerland;
  • Skoda RC; Department of Biomedicine, Experimental Hematology, University Hospital Basel, CH-4031 Basel, Switzerland;
  • Hubbard SR; Kimmel Center for Biology and Medicine at the Skirball Institute and Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016; and.
  • Silvennoinen O; School of Medicine, University of Tampere, FI-33014 Tampere, Finland; Clinical Hematology, Department of Internal Medicine, Tampere University Hospital, FI-33520 Tampere, Finland olli.silvennoinen@uta.fi.
Proc Natl Acad Sci U S A ; 112(15): 4642-7, 2015 Apr 14.
Article en En | MEDLINE | ID: mdl-25825724
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Adenosina Trifosfato / Mutación Missense / Janus Quinasa 2 Límite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Adenosina Trifosfato / Mutación Missense / Janus Quinasa 2 Límite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article