Tumour induced osteomalacia.
J Pak Med Assoc
; 65(2): 220-2, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25842564
ABSTRACT
Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome usually presenting with bone pain, fracture of bones and muscle weakness. It is caused by high serum levels of fibroblast growth factor 23 (FGF- 23), which is a hormone-regulating phosphate, and vitamin D. FGF-23 is secreted by several tumours, especially benign mesenchymal tumours which are very small and difficult to locate. There is a significant delay from onset of symptoms to the diagnosis of this entity dueto occult nature of this disease. We present a case of young male who presented with long history of progressively worsening muscular pain and weakness, rendering the patient confined to bed. Our aim of presenting this patient as a case report is to make physicians realise that any patient with unexplained muscular weakness and pain must undergo workup for TIO, including serum phosphate measurement, as this is a rare but potentially curable disease.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Síndromes Paraneoplásicos
/
Neoplasias de los Tejidos Blandos
/
Articulación de la Rodilla
/
Neoplasias de Tejido Conjuntivo
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Pak Med Assoc
Año:
2015
Tipo del documento:
Article