[SNP microarray analysis of retention abortion chorionic villus].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 32(2): 180-2, 2015 Apr.
Article
en Zh
| MEDLINE
| ID: mdl-25863081
ABSTRACT
OBJECTIVE:
To compare villus cell culture and karyotype analysis with single nucleotide polymorphism (SNP) microarray technology for the detection of chorionic villus chromosome in patients with retention of abortion.METHODS:
Forty cases were analyzed with the two methods.RESULTS:
Chorionic villus culturing was successful in 29 cases, among which 10 were found to have an abnormal karyotypes. For the SNP microarray analysis, all 40 cases were successful, among which 16 were shown to have an abnormal molecular karyotype.CONCLUSION:
SNP microarray technology is highly accurate and specific, which is particularly suitable for the detection of chromosomal deletions or duplications, uniparental disomy, low-percentage mosaicism and other chromosomal abnormalities. It has provided an effective supplement to the conventional chorionic villus culture and karyotype analysis.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vellosidades Coriónicas
/
Aborto Retenido
/
Análisis de Secuencia por Matrices de Oligonucleótidos
Tipo de estudio:
Evaluation_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
Zh
Revista:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
Asunto de la revista:
GENETICA MEDICA
Año:
2015
Tipo del documento:
Article