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Neuroprotection in acute brain injury: an up-to-date review.
Stocchetti, Nino; Taccone, Fabio S; Citerio, Giuseppe; Pepe, Paul E; Le Roux, Peter D; Oddo, Mauro; Polderman, Kees H; Stevens, Robert D; Barsan, William; Maas, Andrew I R; Meyfroidt, Geert; Bell, Michael J; Silbergleit, Robert; Vespa, Paul M; Faden, Alan I; Helbok, Raimund; Tisherman, Samuel; Zanier, Elisa R; Valenzuela, Terence; Wendon, Julia; Menon, David K; Vincent, Jean-Louis.
Afiliación
  • Stocchetti N; Department of Physiopathology and Transplant, Milan University, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy. stocchet@policlinico.mi.it.
  • Taccone FS; Neuro ICU, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy. stocchet@policlinico.mi.it.
  • Citerio G; Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, 1070, Brussels, Belgium. ftaccone@ulb.ac.be.
  • Pepe PE; Department of Health Science, University of Milan-Bicocca, Ospedale San Gerardo, Via Pergolesi 33, 20900, Monza, MB, Italy. g.citerio@hsgerardo.org.
  • Le Roux PD; NeuroIntensive Care, Department of Emergency and Intensive Care, Ospedale San Gerardo, Via Pergolesi 33, 20900, Monza, MB, Italy. g.citerio@hsgerardo.org.
  • Oddo M; Department of Emergency Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 75390-8579, USA. Paul.Pepe@UTSouthwestern.edu.
  • Polderman KH; Department of Neurosurgery, Lankenau Medical Center, Wynnewood, PA, 19096, USA. LeRouxP@MLHS.ORG.
  • Stevens RD; Department of Intensive Care Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Faculty of Biology and Medicine, University of Lausanne, 1011, Lausanne, Switzerland. Mauro.Oddo@chuv.ch.
  • Barsan W; Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA. poldermankh@upmc.edu.
  • Maas AI; Division of Neuroscience Critical Care, Division of Adult Critical Care, Johns Hopkins Medicine, Baltimore, MD, 21287, USA. rstevens@jhmi.edu.
  • Meyfroidt G; NETT Clinical Coordinating Center, University of Michigan, Ann Arbor, MI, 48106-0381, USA. wbarsan@med.umich.edu.
  • Bell MJ; Department of Neurosurgery, University Hospital Antwerp and University of Antwerp, 2650, Edegem, Belgium. andrew.maas@uza.be.
  • Silbergleit R; Department of Intensive Care, UZ Leuven, Campus Gasthuisberg, 3000, Leuven, Belgium. geert.meyfroidt@uzleuven.be.
  • Vespa PM; Department of Critical Care Medicine and the Safar Center for Resuscitation Research, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA. bellmj4@upmc.edu.
  • Faden AI; NETT Clinical Coordinating Center, University of Michigan, Ann Arbor, MI, 48106-0381, USA. robie@med.umich.edu.
  • Helbok R; Department of Neurocritical Care, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. PVespa@mednet.ucla.edu.
  • Tisherman S; Center for Shock, Trauma & Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, MD, 21201, USA. afaden@anes.umm.edu.
  • Zanier ER; Department of Neurology, Neurocritical Care Unit, Innsbruck Medical University, 6020, Innsbruck, Austria. raimund.helbok@uki.at.
  • Valenzuela T; Department of Surgery, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. tishermansa@ccm.upmc.edu.
  • Wendon J; IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Department of Neuroscience, 20156, Milan, Italy. elisa.zanier@marionegri.it.
  • Menon DK; Department of Emergency Medicine, University of Arizona, Tucson, AZ, 85724-5057, USA. hermanos.valenzuela@gmail.com.
  • Vincent JL; Institute of Liver Studies, King's College Hospital, Denmark Hill, London, SE5 9RS, UK. julia.wendon@kcl.ac.uk.
Crit Care ; 19: 186, 2015 Apr 21.
Article en En | MEDLINE | ID: mdl-25896893
Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lesiones Encefálicas / Isquemia Encefálica / Fármacos Neuroprotectores / Accidente Cerebrovascular / Neuroprotección Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Crit Care Año: 2015 Tipo del documento: Article País de afiliación: Italia
Texto completo
Imprimir
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lesiones Encefálicas / Isquemia Encefálica / Fármacos Neuroprotectores / Accidente Cerebrovascular / Neuroprotección Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Crit Care Año: 2015 Tipo del documento: Article País de afiliación: Italia