Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases.
ACS Nano
; 9(6): 5937-46, 2015 Jun 23.
Article
en En
| MEDLINE
| ID: mdl-25905457
ABSTRACT
Implantable endovascular devices such as bare metal, drug eluting, and bioresorbable stents have transformed interventional care by providing continuous structural and mechanical support to many peripheral, neural, and coronary arteries affected by blockage. Although effective in achieving immediate restoration of blood flow, the long-term re-endothelialization and inflammation induced by mechanical stents are difficult to diagnose or treat. Here we present nanomaterial designs and integration strategies for the bioresorbable electronic stent with drug-infused functionalized nanoparticles to enable flow sensing, temperature monitoring, data storage, wireless power/data transmission, inflammation suppression, localized drug delivery, and hyperthermia therapy. In vivo and ex vivo animal experiments as well as in vitro cell studies demonstrate the previously unrecognized potential for bioresorbable electronic implants coupled with bioinert therapeutic nanoparticles in the endovascular system.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Vasculares
/
Stents
/
Implantes Absorbibles
/
Electrónica
/
Nanopartículas
/
Procedimientos Endovasculares
Límite:
Animals
Idioma:
En
Revista:
ACS Nano
Año:
2015
Tipo del documento:
Article