Apparent inosine uptake by the human heart.
Cardiovasc Res
; 23(6): 484-8, 1989 Jun.
Article
en En
| MEDLINE
| ID: mdl-2590921
ABSTRACT
Although inosine has been used clinically to support the myocardium, no data are available on the fate of exogenous inosine in the human heart. We therefore infused six patients, catheterised for coronary angiography, with inosine (5 mg.kg-1.min-1 intravenously) for 6 minutes. Before infusion, the arterio-venous difference of inosine, hypoxanthine and xanthine across the heart was nil. During infusion, arterial inosine increased substantially, exceeding the coronary sinus concentration by a maximum of 200 (SEM 53) mumol.litre-1, p = 0.02, at the fourth minute. Arterial hypoxanthine and xanthine also increased, while the arterio-venous difference became 16(11) and 10(3) (p = 0.04) mumol.litre-1, respectively. Left ventricular dP/dtmax increased by 22(7)% (p = 0.04) at the end of infusion. Thus, there seemed to be substantial uptake of inosine by the human heart, followed by improvement in haemodynamics.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad Coronaria
/
Inosina
/
Miocardio
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cardiovasc Res
Año:
1989
Tipo del documento:
Article
País de afiliación:
Países Bajos