Entry of Ebola Virus is an Asynchronous Process.
J Infect Dis
; 212 Suppl 2: S199-203, 2015 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-25941332
ABSTRACT
Ebola virus (EBOV) is responsible for a severe fever with a high mortality rate. The diverse nature of the attachment of the virus to the cell surface, the initial step of virus entry, raises questions concerning the kinetics of the virus internalization process. We investigated EBOV entry kinetics using the activity of a particular monoclonal antibody that neutralizes virus infectivity. We demonstrate that inoculation of cells with EBOV results in an asynchronous entry process, as revealed by the ability of the virus to remain in a cell-bound state for an extended period of time before it is internalized.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fiebre Hemorrágica Ebola
/
Ebolavirus
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Infect Dis
Año:
2015
Tipo del documento:
Article
País de afiliación:
Francia