Modulating conscious movement intention by noninvasive brain stimulation and the underlying neural mechanisms.
J Neurosci
; 35(18): 7239-55, 2015 May 06.
Article
en En
| MEDLINE
| ID: mdl-25948272
ABSTRACT
Conscious intention is a fundamental aspect of the human experience. Despite long-standing interest in the basis and implications of intention, its underlying neurobiological mechanisms remain poorly understood. Using high-definition transcranial DC stimulation (tDCS), we observed that enhancing spontaneous neuronal excitability in both the angular gyrus and the primary motor cortex caused the reported time of conscious movement intention to be â¼60-70 ms earlier. Slow brain waves recorded â¼2-3 s before movement onset, as well as hundreds of milliseconds after movement onset, independently correlated with the modulation of conscious intention by brain stimulation. These brain activities together accounted for 81% of interindividual variability in the modulation of movement intention by brain stimulation. A computational model using coupled leaky integrator units with biophysically plausible assumptions about the effect of tDCS captured the effects of stimulation on both neural activity and behavior. These results reveal a temporally extended brain process underlying conscious movement intention that spans seconds around movement commencement.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Estado de Conciencia
/
Potenciales Evocados Motores
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Estimulación Transcraneal de Corriente Directa
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Corteza Motora
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Movimiento
Tipo de estudio:
Clinical_trials
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
J Neurosci
Año:
2015
Tipo del documento:
Article