ß-Glucan from Saccharomyces cerevisiae Induces IFN-γ Production In Vivo in BALB/c Mice.
In Vivo
; 29(3): 359-63, 2015.
Article
en En
| MEDLINE
| ID: mdl-25977381
ABSTRACT
AIM:
ß-Glucan is one of the most abundant polymers in nature and has been established as an immunomodulator. This compound has notable physiological effects on mammalian immune systems, including anti-tumor and anti-infective activities and can activate the immune response. It is considered that the immune-stimulating activities of ß-glucan can depend on physicochemical parameters, such as molecular size. Saccharomyces cerevisiae, also known as baker's yeast, is a frequently used source of ß-glucan. The aim of the experiments was to investigate how different Saccharomyces cerevisiae ß-glucan preparations with different molecular size affect interferon-gamma (IFN-γ) production in BALB/c mice. MATERIALS ANDMETHODS:
In vivo and in vitro BALB/c mouse models were used for the investigations. Different ß-glucan preparations were orally administrated in the in vivo experiments. IFN-γ production in BALB/c mice was analyzed by enzyme-linked immunosorbent assay and measuring interferon-γ RNA concentration.RESULTS:
The results showed that orally-administered ß-glucan from S. cerevisiae enhanced IFN-γ production in BALB/c mice in the in vivo model, but not by mouse leukocytes in vitro. Moreover, water-soluble ß-glucan enhanced IFN-γ production more effectively than did particulate ß-glucan.CONCLUSION:
IFN-γ plays an important role in immunity against viral and bacterial infections. Our experiments have shown that ß-glucan preparations enhance IFN-γ production in BALB/c mice and can be potentially used for immune system stimulation in mammals. Current results may be used to develop soluble ß-glucan nutritional supplements.Palabras clave
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Interferón gamma
/
Beta-Glucanos
/
Polisacáridos Fúngicos
/
Factores Inmunológicos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
In Vivo
Asunto de la revista:
NEOPLASIAS
Año:
2015
Tipo del documento:
Article
País de afiliación:
Lituania