Disposition, metabolism and mass balance of delafloxacin in healthy human volunteers following intravenous administration.
Xenobiotica
; 45(12): 1054-62, 2015.
Article
en En
| MEDLINE
| ID: mdl-25986539
ABSTRACT
1. The pharmacokinetics and disposition of delafloxacin was investigated following a single intravenous (300 mg, 100 µCi) dose to healthy male subjects. 2. Mean Cmax, AUC0-∞, Tmax and t1/2 values for delafloxacin were 8.98 µg/mL, 21.31 µg h/mL, 1 h and 2.35 h, respectively, after intravenous dosing. 3. Radioactivity was predominantly excreted via the kidney with 66% of the radioactive dose recovered in the urine. Approximately 29% of the radioactivity was recovered in the faeces, giving an overall mean recovery of 94% administered radioactivity. 4. The predominant circulating components were identified as delafloxacin and a direct glucuronide conjugate of delafloxacin.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fluoroquinolonas
/
Antibacterianos
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Xenobiotica
Año:
2015
Tipo del documento:
Article
País de afiliación:
Reino Unido