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Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB1*07:01.
Parham, L R; Briley, L P; Li, L; Shen, J; Newcombe, P J; King, K S; Slater, A J; Dilthey, A; Iqbal, Z; McVean, G; Cox, C J; Nelson, M R; Spraggs, C F.
Afiliación
  • Parham LR; GlaxoSmithKline Research & Development, Research Triangle Park, NC, USA.
  • Briley LP; GlaxoSmithKline Research & Development, Research Triangle Park, NC, USA.
  • Li L; GlaxoSmithKline Research & Development, Research Triangle Park, NC, USA.
  • Shen J; GlaxoSmithKline Research & Development, Research Triangle Park, NC, USA.
  • Newcombe PJ; GlaxoSmithKline Research & Development, Stevenage, UK.
  • King KS; GlaxoSmithKline Research & Development, Research Triangle Park, NC, USA.
  • Slater AJ; GlaxoSmithKline Research & Development, Research Triangle Park, NC, USA.
  • Dilthey A; Department of Statistics, University of Oxford, Oxford, UK.
  • Iqbal Z; Department of Statistics, University of Oxford, Oxford, UK.
  • McVean G; Department of Statistics, University of Oxford, Oxford, UK.
  • Cox CJ; GlaxoSmithKline Research & Development, Stevenage, UK.
  • Nelson MR; GlaxoSmithKline Research & Development, Research Triangle Park, NC, USA.
  • Spraggs CF; GlaxoSmithKline Research & Development, Stevenage, UK.
Pharmacogenomics J ; 16(2): 180-5, 2016 Apr.
Article en En | MEDLINE | ID: mdl-25987243
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quinazolinas / Enfermedad Hepática Inducida por Sustancias y Drogas / Cadenas HLA-DRB1 / Antineoplásicos Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Pharmacogenomics J Asunto de la revista: BIOLOGIA MOLECULAR / FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quinazolinas / Enfermedad Hepática Inducida por Sustancias y Drogas / Cadenas HLA-DRB1 / Antineoplásicos Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Pharmacogenomics J Asunto de la revista: BIOLOGIA MOLECULAR / FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos