Lymph node fibroblastic reticular cells in health and disease.
Nat Rev Immunol
; 15(6): 350-61, 2015 Jun.
Article
en En
| MEDLINE
| ID: mdl-25998961
ABSTRACT
Over the past decade, a series of discoveries relating to fibroblastic reticular cells (FRCs) immunologically specialized myofibroblasts found in lymphoid tissue has promoted these cells from benign bystanders to major players in the immune response. In this Review, we focus on recent advances regarding the immunobiology of lymph node-derived FRCs, presenting an updated view of crucial checkpoints during their development and their dynamic control of lymph node expansion and contraction during infection. We highlight the robust effects of FRCs on systemic B cell and T cell responses, and we present an emerging view of FRCs as drivers of pathology following acute and chronic viral infections. Lastly, we review emerging therapeutic advances that harness the immunoregulatory properties of FRCs.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Linfocitos T
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Células Dendríticas Foliculares
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Miofibroblastos
/
Infecciones
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Ganglios Linfáticos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2015
Tipo del documento:
Article