Advances and applications of single-cell sequencing technologies.

Wang, Yong; Navin, Nicholas E

Wang, Yong; Navin, Nicholas E.

Afiliación

Wang Y; Department of Genetics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
Navin NE; Department of Genetics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: nnavin@mdanderson.org.

Mol Cell ; 58(4): 598-609, 2015 May 21.

Article en En | MEDLINE | ID: mdl-26000845

ABSTRACT

ABSTRACT

Single-cell sequencing (SCS) has emerged as a powerful new set of technologies for studying rare cells and delineating complex populations. Over the past 5 years, SCS methods for DNA and RNA have had a broad impact on many diverse fields of biology, including microbiology, neurobiology, development, tissue mosaicism, immunology, and cancer research. In this review, we will discuss SCS technologies and applications, as well as translational applications in the clinic.

Asunto(s)

Investigación Biomédica/métodos; Genómica/métodos; Secuenciación de Nucleótidos de Alto Rendimiento/métodos; Análisis de la Célula Individual/métodos; Animales; Investigación Biomédica/tendencias; Predicción; Humanos

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Genómica / Investigación Biomédica / Análisis de la Célula Individual / Secuenciación de Nucleótidos de Alto Rendimiento Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

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