Abbreviated exposure to hypoxia is sufficient to induce CNS dysmyelination, modulate spinal motor neuron composition, and impair motor development in neonatal mice.

Watzlawik, Jens O; Kahoud, Robert J; O'Toole, Ryan J; White, Katherine A M; Ogden, Alyssa R; Painter, Meghan M; Wootla, Bharath; Papke, Louisa M; Denic, Aleksandar; Weimer, Jill M; Carey, William A; Rodriguez, Moses

Watzlawik, Jens O; Kahoud, Robert J; O'Toole, Ryan J; White, Katherine A M; Ogden, Alyssa R; Painter, Meghan M; Wootla, Bharath; Papke, Louisa M; Denic, Aleksandar; Weimer, Jill M; Carey, William A; Rodriguez, Moses.

Afiliación

Watzlawik JO; Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Kahoud RJ; Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America; Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
O'Toole RJ; Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, United States of America.
White KA; Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, United States of America.
Ogden AR; Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, United States of America.
Painter MM; Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Wootla B; Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Papke LM; Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Denic A; Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Weimer JM; Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota, United States of America.
Carey WA; Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Rodriguez M; Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.

PLoS One ; 10(5): e0128007, 2015.

Article en En | MEDLINE | ID: mdl-26020269

Asunto(s)

Hipoxia-Isquemia Encefálica/metabolismo; Neuronas Motoras/metabolismo; Células-Madre Neurales/metabolismo; Sustancia Blanca/metabolismo; Animales; Animales Recién Nacidos; Modelos Animales de Enfermedad; Proteína Homeobox Nkx-2.2; Proteínas de Homeodominio; Humanos; Hipoxia-Isquemia Encefálica/patología; Ratones; Neuronas Motoras/patología; Vaina de Mielina/metabolismo; Vaina de Mielina/patología; Proteínas del Tejido Nervioso/biosíntesis; Células-Madre Neurales/patología; Proteínas Nucleares; Oligodendroglía/metabolismo; Oligodendroglía/patología; Factores de Transcripción; Sustancia Blanca/patología

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hipoxia-Isquemia Encefálica / Células-Madre Neurales / Sustancia Blanca / Neuronas Motoras Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

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