The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function.

Tembe, Varsha; Martino-Echarri, Estefania; Marzec, Kamila A; Mok, Myth T S; Brodie, Kirsty M; Mills, Kate; Lei, Ying; DeFazio, Anna; Rizos, Helen; Kettle, Emma; Boadle, Ross; Henderson, Beric R

Tembe, Varsha; Martino-Echarri, Estefania; Marzec, Kamila A; Mok, Myth T S; Brodie, Kirsty M; Mills, Kate; Lei, Ying; DeFazio, Anna; Rizos, Helen; Kettle, Emma; Boadle, Ross; Henderson, Beric R.

Afiliación

Tembe V; Centre for Cancer Research, The Westmead Millennium Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, Australia.
Martino-Echarri E; Centre for Cancer Research, The Westmead Millennium Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, Australia.
Marzec KA; Centre for Cancer Research, The Westmead Millennium Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, Australia.
Mok MT; Centre for Cancer Research, The Westmead Millennium Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, Australia.
Brodie KM; Centre for Cancer Research, The Westmead Millennium Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, Australia.
Mills K; Centre for Cancer Research, The Westmead Millennium Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, Australia.
Lei Y; Centre for Cancer Research, The Westmead Millennium Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, Australia.
DeFazio A; Centre for Cancer Research, The Westmead Millennium Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, Australia.
Rizos H; Centre for Cancer Research, The Westmead Millennium Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, Australia.
Kettle E; Electron Microscopy Unit, Institute for Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW 2145, Australia.
Boadle R; Electron Microscopy Unit, Institute for Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW 2145, Australia.
Henderson BR; Centre for Cancer Research, The Westmead Millennium Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, Australia. Electronic address: beric.henderson@sydney.edu.au.

Cell Signal ; 27(9): 1763-71, 2015 Sep.

Article en En | MEDLINE | ID: mdl-26022179

Asunto(s)

Apoptosis; Neoplasias de la Mama/metabolismo; Citoplasma/metabolismo; Mitocondrias/metabolismo; Proteína p53 Supresora de Tumor/metabolismo; Proteínas Supresoras de Tumor/metabolismo; Ubiquitina-Proteína Ligasas/metabolismo; Secuencia de Aminoácidos; Neoplasias de la Mama/genética; Neoplasias de la Mama/patología; Citoplasma/genética; Roturas del ADN; Femenino; Humanos; Células MCF-7; Mitocondrias/genética; Mitocondrias/patología; Estructura Terciaria de Proteína; Transporte de Proteínas/genética; Proteínas Proto-Oncogénicas c-bcl-2/genética; Proteínas Proto-Oncogénicas c-bcl-2/metabolismo; Eliminación de Secuencia; Proteína p53 Supresora de Tumor/genética; Proteínas Supresoras de Tumor/genética; Ubiquitina-Proteína Ligasas/genética; Proteína X Asociada a bcl-2/genética; Proteína X Asociada a bcl-2/metabolismo

Palabras clave

Apoptosis; BARD1; BCL-2; Mitochondria; p53

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Proteína p53 Supresora de Tumor / Apoptosis / Citoplasma / Proteínas Supresoras de Tumor / Ubiquitina-Proteína Ligasas / Mitocondrias Límite: Female / Humans Idioma: En Revista: Cell Signal Año: 2015 Tipo del documento: Article País de afiliación: Australia

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