Cockroach sensitization mitigates allergic rhinoconjunctivitis symptom severity in patients allergic to house dust mites and pollen.
J Allergy Clin Immunol
; 136(3): 658-66, 2015 Sep.
Article
en En
| MEDLINE
| ID: mdl-26026342
ABSTRACT
BACKGROUND:
Modifiers of symptom severity in patients with allergic rhinoconjunctivitis (AR) are imprecisely characterized. The hygiene hypothesis implicates childhood microbial exposure as a protective factor. Cockroach sensitization (C+) might be a proxy for microbial exposure.OBJECTIVE:
We sought to determine whether C+ assayed by means of skin prick tests influenced AR symptom severity in controlled and natural settings.METHODS:
Total symptom scores (TSSs) were recorded by 21 participants with house dust mite allergy (M+) in the natural setting and during repeated exposures of 3 hours per day to house dust mite allergen in an allergen challenge chamber (ACC). In M+ participants the peripheral blood and nasal cells were assayed for T-cell activation and transcriptomic profiles (by using RNA sequencing), respectively. Participants allergic to mountain cedar (n = 21), oak (n = 34), and ragweed (n = 23) recorded TSSs during separate out-of-season exposures to these pollens (any pollen sensitization [P+]) in the ACC; a subset recorded TSSs in the pollination seasons.RESULTS:
The hierarchy of TSSs (highest to lowest) among M+ participants tracked the following skin prick test sensitization statuses M+P+C- > M+P+C+ > M+P-C- > M+P-C+. In nasal cells and peripheral blood the immune/inflammatory responses were rapidly resolved in M+P+C+ compared with M+P+C- participants. Among those allergic to pollen, C+ was associated with a lower TSS during pollen challenges and the pollination season. After aggregated analysis of all 4 ACC studies, C+ status was associated with a 2.8-fold greater likelihood of a lower TSS compared with C- status (odds ratio, 2.78; 95% CI, 1.18-6.67; P = .02).CONCLUSIONS:
C+ status is associated with mitigation of AR symptom severity in adults with AR.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polen
/
Conjuntivitis Alérgica
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Alérgenos
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Rinitis Alérgica Estacional
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Desensibilización Inmunológica
/
Cucarachas
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Adult
/
Animals
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Allergy Clin Immunol
Año:
2015
Tipo del documento:
Article