Oral and Vaginal Tenofovir for Genital Herpes Simplex Virus Type 2 Shedding in Immunocompetent Women: A Double-Blind, Randomized, Cross-over Trial.

Bender Ignacio, Rachel A; Perti, Tara; Magaret, Amalia S; Rajagopal, Sharanya; Stevens, Claire E; Huang, Meei-Li; Selke, Stacy; Johnston, Christine; Marrazzo, Jeanne; Wald, Anna

Bender Ignacio, Rachel A; Perti, Tara; Magaret, Amalia S; Rajagopal, Sharanya; Stevens, Claire E; Huang, Meei-Li; Selke, Stacy; Johnston, Christine; Marrazzo, Jeanne; Wald, Anna.

Afiliación

Bender Ignacio RA; Division of Allergy and Infectious Diseases, Department of Medicine Department of Medicine Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Perti T; Division of Allergy and Infectious Diseases, Department of Medicine Department of Medicine.
Magaret AS; Department of Laboratory Medicine Department of Biostatistics Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Rajagopal S; Department of Epidemiology, University of Washington Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Stevens CE; Department of Medicine.
Huang ML; Department of Laboratory Medicine Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Selke S; Department of Laboratory Medicine.
Johnston C; Division of Allergy and Infectious Diseases, Department of Medicine Department of Medicine Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Marrazzo J; Division of Allergy and Infectious Diseases, Department of Medicine Department of Medicine.
Wald A; Division of Allergy and Infectious Diseases, Department of Medicine Department of Medicine Department of Laboratory Medicine Department of Epidemiology, University of Washington Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

J Infect Dis ; 212(12): 1949-56, 2015 Dec 15.

Article en En | MEDLINE | ID: mdl-26044291

Asunto(s)

Antivirales/uso terapéutico; Herpes Genital/tratamiento farmacológico; Herpesvirus Humano 2/aislamiento & purificación; Tenofovir/uso terapéutico; Esparcimiento de Virus; Administración Intravaginal; Administración Oral; Adulto; Estudios Cruzados; Método Doble Ciego; Femenino; Herpes Genital/patología; Humanos; Persona de Mediana Edad; Placebos/administración & dosificación; Resultado del Tratamiento

Palabras clave

HIV acquisition; HSV-2 transmission; genital herpes; herpes simplex virus-2 (HSV-2); tenofovir; vaginal microbicide

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antivirales / Herpes Genital / Esparcimiento de Virus / Herpesvirus Humano 2 / Tenofovir Tipo de estudio: Clinical_trials / Etiology_studies / Guideline Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: J Infect Dis Año: 2015 Tipo del documento: Article

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