Experimental models of liver fibrosis.
Arch Toxicol
; 90(5): 1025-1048, 2016 May.
Article
en En
| MEDLINE
| ID: mdl-26047667
ABSTRACT
Hepatic fibrosis is a wound healing response to insults and as such affects the entire world population. In industrialized countries, the main causes of liver fibrosis include alcohol abuse, chronic hepatitis virus infection and non-alcoholic steatohepatitis. A central event in liver fibrosis is the activation of hepatic stellate cells, which is triggered by a plethora of signaling pathways. Liver fibrosis can progress into more severe stages, known as cirrhosis, when liver acini are substituted by nodules, and further to hepatocellular carcinoma. Considerable efforts are currently devoted to liver fibrosis research, not only with the goal of further elucidating the molecular mechanisms that drive this disease, but equally in view of establishing effective diagnostic and therapeutic strategies. The present paper provides a state-of-the-art overview of in vivo and in vitro models used in the field of experimental liver fibrosis research.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cicatrización de Heridas
/
Células Estrelladas Hepáticas
/
Hígado
/
Cirrosis Hepática Experimental
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Arch Toxicol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Bélgica