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Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes.
Karakikes, Ioannis; Ameen, Mohamed; Termglinchan, Vittavat; Wu, Joseph C.
Afiliación
  • Karakikes I; From the Stanford Cardiovascular Institute (I.K., M.A., V.T., J.C.W.), Department of Medicine, Division of Cardiovascular Medicine (I.K., V.T., J.C.W.), and Institute of Stem Cell Biology and Regenerative Medicine (J.C.W.), Stanford University School of Medicine, CA. ioannis1@stanford.edu joewu@stan
  • Ameen M; From the Stanford Cardiovascular Institute (I.K., M.A., V.T., J.C.W.), Department of Medicine, Division of Cardiovascular Medicine (I.K., V.T., J.C.W.), and Institute of Stem Cell Biology and Regenerative Medicine (J.C.W.), Stanford University School of Medicine, CA.
  • Termglinchan V; From the Stanford Cardiovascular Institute (I.K., M.A., V.T., J.C.W.), Department of Medicine, Division of Cardiovascular Medicine (I.K., V.T., J.C.W.), and Institute of Stem Cell Biology and Regenerative Medicine (J.C.W.), Stanford University School of Medicine, CA.
  • Wu JC; From the Stanford Cardiovascular Institute (I.K., M.A., V.T., J.C.W.), Department of Medicine, Division of Cardiovascular Medicine (I.K., V.T., J.C.W.), and Institute of Stem Cell Biology and Regenerative Medicine (J.C.W.), Stanford University School of Medicine, CA. ioannis1@stanford.edu joewu@stan
Circ Res ; 117(1): 80-8, 2015 Jun 19.
Article en En | MEDLINE | ID: mdl-26089365
ABSTRACT
Disease models are essential for understanding cardiovascular disease pathogenesis and developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology has generated significant enthusiasm for its potential application in basic and translational cardiac research. Patient-specific iPSC-derived cardiomyocytes offer an attractive experimental platform to model cardiovascular diseases, study the earliest stages of human development, accelerate predictive drug toxicology tests, and advance potential regenerative therapies. Harnessing the power of iPSC-derived cardiomyocytes could eliminate confounding species-specific and interpersonal variations and ultimately pave the way for the development of personalized medicine for cardiovascular diseases. However, the predictive power of iPSC-derived cardiomyocytes as a valuable model is contingent on comprehensive and rigorous molecular and functional characterization.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Técnicas de Cultivo de Célula / Miocitos Cardíacos / Células Madre Pluripotentes Inducidas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Circ Res Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Técnicas de Cultivo de Célula / Miocitos Cardíacos / Células Madre Pluripotentes Inducidas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Circ Res Año: 2015 Tipo del documento: Article