Unusual Femur Stress Fractures in Children With Osteogenesis Imperfecta and Intramedullary Rods on Long-term Intravenous Pamidronate Therapy.
J Pediatr Orthop
; 36(7): 757-61, 2016.
Article
en En
| MEDLINE
| ID: mdl-26090982
ABSTRACT
In this report, we describe 6 children with osteogenesis imperfecta with unusual stress femoral fractures. All children were on long-term cyclic pamidronate treatment. All fractures occurred without trauma or with minimal trauma and were located in the subtrochanteric or the diaphyseal regions of the femur over preexisting intramedullary rods. These fractures have very similar features to the reported minimal trauma atypical femoral fractures in adults on long-term bisphosphonate treatment. These fractures raise concerns about the role of prolonged remodeling suppression and microdamage accumulation and the risk of increased bone fragility.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Osteogénesis Imperfecta
/
Fracturas por Estrés
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Difosfonatos
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Fracturas del Fémur
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Fémur
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Fijación Intramedular de Fracturas
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Límite:
Adolescent
/
Child
/
Female
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Humans
/
Male
Idioma:
En
Revista:
J Pediatr Orthop
Año:
2016
Tipo del documento:
Article
País de afiliación:
Canadá