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Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115.
Mortensen, Deborah S; Perrin-Ninkovic, Sophie M; Shevlin, Graziella; Elsner, Jan; Zhao, Jingjing; Whitefield, Brandon; Tehrani, Lida; Sapienza, John; Riggs, Jennifer R; Parnes, Jason S; Papa, Patrick; Packard, Garrick; Lee, Branden G S; Harris, Roy; Correa, Matthew; Bahmanyar, Sogole; Richardson, Samantha J; Peng, Sophie X; Leisten, Jim; Khambatta, Godrej; Hickman, Matt; Gamez, James C; Bisonette, René R; Apuy, Julius; Cathers, Brian E; Canan, Stacie S; Moghaddam, Mehran F; Raymon, Heather K; Worland, Peter; Narla, Rama Krishna; Fultz, Kimberly E; Sankar, Sabita.
Afiliación
  • Mortensen DS; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Perrin-Ninkovic SM; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Shevlin G; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Elsner J; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Zhao J; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Whitefield B; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Tehrani L; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Sapienza J; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Riggs JR; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Parnes JS; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Papa P; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Packard G; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Lee BG; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Harris R; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Correa M; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Bahmanyar S; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Richardson SJ; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Peng SX; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Leisten J; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Khambatta G; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Hickman M; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Gamez JC; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Bisonette RR; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Apuy J; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Cathers BE; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Canan SS; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Moghaddam MF; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Raymon HK; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Worland P; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Narla RK; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Fultz KE; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
  • Sankar S; Celgene Corporation, 10300 Campus Pointe Drive, Suite 100, San Diego, California 92121, United States.
J Med Chem ; 58(14): 5599-608, 2015 Jul 23.
Article en En | MEDLINE | ID: mdl-26102506
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazinas / Triazoles / Diseño de Fármacos / Inhibidores de Proteínas Quinasas / Serina-Treonina Quinasas TOR Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazinas / Triazoles / Diseño de Fármacos / Inhibidores de Proteínas Quinasas / Serina-Treonina Quinasas TOR Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos