Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.

Joo, Yuyoung; Schumacher, Benjamin; Landrieu, Isabelle; Bartel, Maria; Smet-Nocca, Caroline; Jang, Ahram; Choi, Hee Soon; Jeon, Noo Li; Chang, Keun-A; Kim, Hye-Sun; Ottmann, Christian; Suh, Yoo-Hun

Joo, Yuyoung; Schumacher, Benjamin; Landrieu, Isabelle; Bartel, Maria; Smet-Nocca, Caroline; Jang, Ahram; Choi, Hee Soon; Jeon, Noo Li; Chang, Keun-A; Kim, Hye-Sun; Ottmann, Christian; Suh, Yoo-Hun.

Afiliación

Joo Y; *Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Council, and School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea; Department of Pharmacology, College of Medicine, Gachon University, Incheon, Republ
Schumacher B; *Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Council, and School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea; Department of Pharmacology, College of Medicine, Gachon University, Incheon, Republ
Landrieu I; *Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Council, and School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea; Department of Pharmacology, College of Medicine, Gachon University, Incheon, Republ
Bartel M; *Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Council, and School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea; Department of Pharmacology, College of Medicine, Gachon University, Incheon, Republ
Smet-Nocca C; *Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Council, and School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea; Department of Pharmacology, College of Medicine, Gachon University, Incheon, Republ
Jang A; *Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Council, and School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea; Department of Pharmacology, College of Medicine, Gachon University, Incheon, Republ
Choi HS; *Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Council, and School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea; Department of Pharmacology, College of Medicine, Gachon University, Incheon, Republ
Jeon NL; *Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Council, and School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea; Department of Pharmacology, College of Medicine, Gachon University, Incheon, Republ
Chang KA; *Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Council, and School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea; Department of Pharmacology, College of Medicine, Gachon University, Incheon, Republ
Kim HS; *Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Council, and School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea; Department of Pharmacology, College of Medicine, Gachon University, Incheon, Republ
Ottmann C; *Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Council, and School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea; Department of Pharmacology, College of Medicine, Gachon University, Incheon, Republ
Suh YH; *Department of Pharmacology, College of Medicine and Neuroscience Research Institute, Medical Research Council, and School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea; Department of Pharmacology, College of Medicine, Gachon University, Incheon, Republ

FASEB J ; 29(10): 4133-44, 2015 Oct.

Article en En | MEDLINE | ID: mdl-26103986

Asunto(s)

Proteínas 14-3-3/metabolismo; Axones/metabolismo; Biomarcadores de Tumor/metabolismo; Exorribonucleasas/metabolismo; Tubulina (Proteína)/metabolismo; Proteínas tau/metabolismo; Proteínas 14-3-3/química; Proteínas 14-3-3/genética; Axones/fisiología; Sitios de Unión/genética; Biomarcadores de Tumor/química; Biomarcadores de Tumor/genética; Western Blotting; Línea Celular Tumoral; Células Cultivadas; Cristalografía por Rayos X; Citoesqueleto/metabolismo; Exorribonucleasas/química; Exorribonucleasas/genética; Humanos; Espectroscopía de Resonancia Magnética; Microscopía Confocal; Modelos Moleculares; Mutación; Neuritas/metabolismo; Neuritas/fisiología; Neuronas/metabolismo; Fosforilación; Unión Proteica; Estructura Terciaria de Proteína; Serina/química; Serina/genética; Serina/metabolismo; Tauopatías/genética; Tauopatías/metabolismo; Proteínas tau/química; Proteínas tau/genética

Palabras clave

Alzheimer's disease; NMR spectroscopy; X-ray crystallography; phosphorylation; protein-protein interactions

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Axones / Tubulina (Proteína) / Biomarcadores de Tumor / Proteínas tau / Proteínas 14-3-3 / Exorribonucleasas Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2015 Tipo del documento: Article

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